Figure 7

Affected functional processes in sarcomeres and mitochondria of the remote myocardium. (a) Cumulative distributions of all Zq values from proteins in the categories depicted in (Supplementary Figure S3) after 120 min (left) or 7 days (right) of reperfusion; for clarity, all proteins belonging to mitochondrial electron transport chain (ETC) complexes are grouped into one category. (b) Outline of the mechanical uncoupling within the contractile machinery and the transient decrease in processes crucial for energy production (tricarboxylic acid (TCA) cycle, fatty-acid beta-oxidation, mitochondrial complexes III and IV) and energy transfer and supply (mitochondrial substrate/solute carrier proteins). For clarity, mitochondrial complexes are drawn as simple entities, neglecting their complex structures. Graphical elements in Fig. 7 were adapted from the Servier Medical Art Powerpoint image bank. Servier Medical Art by Servier (http://www.servier.com/Powerpoint-image-bank) is licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/).