Table 3 ROC analysis of serum biomarkers individually and combined for GC detection

From: Three-dimensional combined biomarkers assay could improve diagnostic accuracy for gastric cancer

Models

AUC(95%CI)

P -value

Single-model

PGI

0.549(0.506–0.595)

 

PGII

0.641(0.596–0.682)

PGI/II

0.735(0.696–0.773)

HpAb

0.736(0.700–0.775)

OPN

0.715(0.675–0.752)

Dual-model

PGI/II-OPN

0.787(0.752–0.822)

<0.001a, <0.001b

PGI/II-HpAb

0.786(0.751–0.820)

<0.001a, <0.001c

OPN- HpAb

0.801(0.768–0.834)

<0.001b, <0.001c

Tri-model

PGI/II-HpAb-OPN

0.826(0.795–0.858)

<0.001d, <0.001e,0.006f

Lauren classification

intestinal

0.827(0.796–0.858)

0.219g

diffuse

0.826(0.795–0.858)

Tumor stage

early

0.821(0.789–0.852)

0.469h

late

0.816(0.784–0.848)

  1. aCompared with the AUC of PGI/II.
  2. bCompared with the AUC of OPN.
  3. cCompared with the AUC of HpAb.
  4. dCompared with the AUC of PGI/II-OPN.
  5. eCompared with the AUC of PGI/II-HpAb.
  6. fCompared with the AUC of OPN- HpAb.
  7. gCompared with the AUC between Lauren classification.
  8. hCompared with the AUC between stage.
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