Figure 2
Honokiol protects mitochondrial respiration capacities in mice suffering Dox-induced cardiotoxicity. (A) Representative profiles of 6 different experiments in each group. (B) Basal mitochondrial respiration capacities (Routine), (C) Maximal phosphorylating respiration capacity via convergent input through complexes I and II (OXPHOS CI + CII). (D) The maximal uncoupled respiratory capacity of the ETS (ETS CI + CII). (E) Inhibition of the phosphorylation system by oligomycin (LEAK CI + CII). (F) Respiratory control ratio (RCR). n = 6, *p < 0.05, **p < 0.01 vs. Control group; vs. Dox group, #p < 0.05, ##p < 0.01. Values are expressed as mean ± SEM.
