Table 1 Honokiol improves cardiac dysfunction after acute Dox treatment.

From: Honokiol protects against doxorubicin cardiotoxicity via improving mitochondrial function in mouse hearts

 

Control (n = 4)

Honokiol (n = 5)

Dox (n = 5)

Dox + Honokiol (n = 5)

LVPW;d (mm)

0.65 ± 0.03

0.63 ± 0.01

0.57 ± 0.02*

0.64 ± 0.02#

LVPW;s (mm)

1.06 ± 0.03

1.06 ± 0.04

0.94 ± 0.02*

1.1 ± 0.03##

LV Vol;d (µl)

80.31 ± 4.17

68.93 ± 3.71

56.47 ± 7.86*

60.94 ± 5.33*

LV Vol;s (µl)

30.44 ± 3.33

26.69 ± 2.43

24.41 ± 5.02

19.87 ± 1.88

LVID;d (mm)

4.24 ± 0.09

3.97 ± 0.09

3.62 ± 0.22*

3.76 ± 0.13*

LVID;s (mm)

2.82 ± 0.13

2.675 ± 0.11

2.351 ± 0.27

2.373 ± 0.09

  1. Echocardiographic measurement in mice after acute Dox treatment. LVPW;d: Left Ventricular Posterior Wall, diastole; LVPW;s: Left Ventricular Posterior Wall, systole; LVID;d: Left Ventricular Internal Dimension diastole; LVID;s: Left Ventricular Internal Dimension, systole. n = 4–5. *p < 0.05 vs. Control group; **p < 0.01 vs. Control group; #p < 0.05 vs. Dox group; ##p < 0.01vs. Dox group. Values are expressed as mean ± SEM.
Back to article page