Figure 4
From: Identification of neuraminidase inhibitors against dual H274Y/I222R mutant strains
Identified NA inhibitors. (A–C) 2D structures of identified compounds. (D–F) Docked conformations of the inhibitors in H1N1 (residues in purple). (G) Enzyme-based assays of the inhibitors. Experiments performed in triplicate. Standard deviation is listed as shown. (H) The fold change in IC50 values of the inhibitors for H274Y, I222R, and H274 and I222R mutant strains. The green dashes represent hydrogen-bonding interactions. Anchors and residues are listed as shown.
