Figure 5
From: Identification of neuraminidase inhibitors against dual H274Y/I222R mutant strains
Identified compounds do not form interactions with mutant residues. (A) The cartoon model for a wild type and dual mutation of H5N1 (PDB ID: 2HTY) are superimposed. Mutant residues are labeled as shown. The identified compounds (B) NSC45174, (C) NSC162535, and (D) NSC45609 were docked into both wild type and the MDR NA with their poses superimposed. The compounds show similar binding conformation and do not form interactions with the mutant site.
