Figure 1
From: Striking diflubenzuron resistance in Culex pipiens, the prime vector of West Nile Virus
Schematic representation of the Chitin Synthase and the position of the diflubenzuron resistance mutations. NTR, N-terminal region; CD, catalytic domain; CTR, C-terminal region; 5TMS, cluster of five transmembrane segments; and CC, coiled-coil motif. Rectangular boxes represent transmembrane domains. Arrows point to signature sequences QRRRW (catalytic domain) and WGTR (N-terminal region). Lower part: Aligned amino acid sequences of the fifth helix of the 5TMS (gray rectangular) from different insects. An arrow points to the position I1043 (Cx. pipiens numbering), where the diflubenzuron resistance mutations I1043M and I1043L are found (adapted from ref.25).
