Figure 8 | Scientific Reports

Figure 8

From: Muscle hypertrophy in hypoxia with inflammation is controlled by bromodomain and extra-terminal domain proteins

Figure 8

Effects of pulmonary inflammation + hypoxia exposure and I-BET151 administration on the MuRF-1 mRNA contents determined by RT-PCR (a) and the myogenin contents (b) determined by Western blot (c), in soleus muscle subjected to an overload surgery. (n = 5–8; Mean ± SEM); Hprt1 was used as housekeeping gene. NCv: Normoxia control + vehicle; NCiB: Normoxia control + IBET; NSv: Normoxia + Surgery + vehicle; NSiB: Normoxia + Surgery + IBET; HSIv: Hypoxia + Surgery + Inflammation + vehicle; HSIiB: Hypoxia + Surgery + Inflammation + IBET. *Different vs. NCv, NCiB, p < 0.05. Blot image has been cropped to the area of interest. The full-length blot is presented in Supplementary Figure 3.

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