Figure 3
From: Estrogenic vascular effects are diminished by chronological aging
The acute responses of murine tail arteries to estrogenic compounds are impaired by aging. Tail arteries from 3- (n = 12), 24- (n = 10) and 29-month-old (n = 5) mice were mounted on a wire myograph and exposed to the thromboxane agonist U4 (10−6M, A). Following steady-state constriction, endothelium-dependent relaxation was assessed by the addition of acetylcholine (10−5M, B). *P < 0.05 from young mice (unpaired t-test). Acute relaxations to 17β (C), PPT (D) and DPN (E) were compared in tail arteries from 3- (n = 8), 24- (n = 9) and 29-month-old (n = 5) female mice. *P < 0.05 from young mice (repeated measures two-way ANOVA). Data are presented as mean ± SEM.
