Figure 4
From: Estrogenic vascular effects are diminished by chronological aging
Vasoactive properties and estrogenic responsiveness of human uterine arteries are attenuated in post-menopausal women. Uterine arteries were mounted on a wire myograph and exposed to the thromboxane agonist U4 (10−6M, A). Following steady-state constriction, endothelium-dependent relaxation was assessed by the addition of bradykinin (10−5M, B). Contractility and endothelial-dependent relaxations were compared in arteries from pre- (n = 26) and post-menopausal (n = 16) women. *P < 0.05 from pre-menopausal women (unpaired t-test). Acute relaxations to 17β (C), PPT (D) and DPN (E) were compared in uterine arteries from pre- (n = 20) and post-menopausal women (n = 13). *P < 0.05 from pre-menopausal women (repeated measures two-way ANOVA). Pre-MW = pre-menopausal women. Post-MW = post-menopausal women. Data are presented as mean ± SEM.
