Figure 2

Microarray Analysis of Enriched CECs. An 11-gene signature for AMI was determined from microarray gene expression analysis of enriched CECs from healthy control and AMI patients. (A,B) Heat maps for the 11 genes in the microarray of the (A) discovery cohort of healthy control (n = 22) and AMI patients (n = 21) and (B) replication cohort of healthy control (n = 25) and AMI patients (n = 23) found in the elastic net to discriminate AMI from control. Samples are ordered according to their predicted probability of being an AMI. Expression levels are represented from high (blue) to low (red). (C,D) ROC-curves for the 11-gene signature in the (C) discovery cohort with AUC of 1.0 (p = 1.90 × 10⁻¹² and (D) validation cohort with AUC of 0.99 (p = 7.78 × 10⁻¹³).