Table 1 Effect of polydatin on anti-DNP IgE-mediated passive cutaneous anaphylaxis in mice

From: Polydatin inhibits mast cell-mediated allergic inflammation by targeting PI3K/Akt, MAPK, NF-κB and Nrf2/HO-1 pathways

Treatment (mg/kg BW)

Anti-DNP IgE

Amount of Evans blue (μg/g)

Inhibition (%)

Normal

 

−

45.68 ± 3.29

—

Polydatin

15

−

48.34 ± 4.02

—

30

−

46.37 ± 5.12

—

45

−

49.59 ± 6.34

—

Control

 

+

234.57 ± 11.86

—

Polydatin

15

+

213.46 ± 10.38

12.58

30

+

162.45 ± 9.28*

38.55

45

+

145.23 ± 9.12**

49.37

  1. Note: Amount of Evans blue was presented as means ± S.E.M. of five independent experiments. Inhibition rate (%) = {1-(T-B)/(C-N)} ×100. Control (C): IgE (+), polydatin (−); Normal (N): IgE (−), polydatin (−); Test (T): IgE (+), polydatin (+); Blank (B): IgE (−), polydatin (+). *p < 0.05 and **p < 0.01 compared with the group sensitized with anti-DNP IgE and challenged with DNP-HAS in the absence of polydatin.
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