Table 2 Effect of polydatin on anti-DNP IgE-mediated passive systemic anaphylaxis in mice.

From: Polydatin inhibits mast cell-mediated allergic inflammation by targeting PI3K/Akt, MAPK, NF-κB and Nrf2/HO-1 pathways

Treatment (mg/kg BW)

Anti-DNP IgE

Histamine concentration (μg/ml)

Inhibition (%)

Normal

 

−

0.10 ± 0.02

—

Polydatin

15

−

0.09 ± 0.01

—

30

−

0.12 ± 0.03

—

45

−

0.11 ± 0.02

—

Control

 

+

1.32 ± 0.16

—

Polydatin

15

+

1.13 ± 0.21

14.75

30

+

0.83 ± 0.19*

39.34

45

+

0.61 ± 0.14**

59.02

  1. Note: Serum histamine concentration was presented as means ± S.E.M. of five independent experiments. Inhibition rate (%) = {1-(T-B)/(C-N)} ×100. Control (C): IgE (+), polydatin (−); Normal (N): IgE (−), polydatin (−); Test (T): IgE (+), polydatin (+); Blank (B): IgE (−), polydatin (+). *p < 0.05 and **p < 0.01 compared with the group sensitized with anti-DNP IgE and challenged with DNP-HAS in the absence of polydatin.
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