Figure 9

Treatment with a combination of NBQX and ifenprodil during the latent period of the intrahippocampal kainate mouse model reduces granule cell dispersion and number of Fluoro-Jade C (FJC) stained neurons in the ipsilateral hippocampus at one week after kainate. As shown in A and B, granule cell dispersion was only observed in the ipsilateral hippocampus and its severity was reduced by drug treatment. As shown in C–F, FJC-stained neurons were observed in CA1, CA3 and hilus of the ipsilateral hippocampus, but in the dentate hilus only vehicle-treated mice significantly differed from naive controls. In all graphs, individual data are shown; the group median is indicated by the horizontal line. Significant differences to naive controls are indicated by asterisk (*P < 0.05; **P < 0.01), while significant differences between vehicle and drug treated groups are indicated by circle (P < 0.05).