Figure 5
Ex vivo fluorescence imaging study. (a,b) The findings of the ex vivo fluorescence imaging study at 1 day after the injection. The upper and lower panels show macrographs and fluorescence images, respectively. Alexa Fluor 647-labelled anti-TF 1849 IgG (left panels) more efficiently accumulated in the intracranial tumours overexpressing TF compared with Alexa Fluor 647-labelled control IgG (right panels). (c) Quantitative analysis of the ex vivo fluorescence imaging study showed significant differences in the relative mean intensity of the intracranial tumours between the fluorescent anti-TF 1849 IgG-administered and control IgG-administered groups. However, there was no significant difference in the other organs between both groups. N = 4 mice per group. The data are shown as the means ± SD. *P = 0.029.
