Figure 3 | Scientific Reports

Figure 3

From: Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes

Figure 3

Results of functional protein interaction network and pathway analysis. (A) Comparison of the top 10 canonical pathways enriched from IPA analysis of differentially regulated proteins (glaucoma vs. control) from vitreous and retina tissues. The significance of functional enrichment is plotted on the y-axis as the −log (p-value). (B) Retinal Reactome functional interaction networks analyzed by the Reactome FI Cytoscape plugin. Of 355 retinal differentially expressed proteins, 136 proteins had at least one other known functional connection. Network nodes are labeled with gene symbols. The Reactome plugin was used to assign functional clusters, which were color-coded and labelled with representative broad functions. (C) Reactome network in (B) color-coded by log2 (glaucoma/control) relative abundance quantified from the TMT analysis.

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