Table 1 Baseline clinicopathological characteristics, n = 68.

From: Immunological tumor status may predict response to neoadjuvant chemotherapy and outcome after radical cystectomy in bladder cancer

Characteristic, n = 68

 

n (%)

Age (years)

Mean/median (range)

64/65 (47–76)

Gender

Male

58 (85)

Smoking (current or past)

Yes

52 (76)

cT category (TUR-BT’)

T2

48 (71)

T3

18 (27)

T4

2 (3)

CIS1 (TUR-BT’)

Yes

15 (22)

LVI2 (TUR-BT’)

Yes

17 (25)

Tumor size (mm) (TUR-BT’)

Mean/median (range)

23/19 (1–70)

pT category (RC”)

T0

28 (41)

pTa, pTcis, pT1

15 (22)

pT2

10 (15)

pT3

10 (15)

pT4

5 (7)

pN category (RC”)

Positive

7 (11)

Negative

58 (89)

Neoadjuvant chemotherapy

Cisplatin-Gemcitabine

64 (94)

Carboplatin-Gemcitabine

4 (6)

Chemotherapy cycles (number)

Mean/median (range)

3/4 (2–6)3

Adjuvant chemotherapy

Yes

6 (9)

Follow-up time (years)

Mean/median (range)

3.3/3.6 (0.25–7.7)

Status

Alive, no evidence of disease

53 (78)

Death due bladder cancer

13 (19)

Death due other reason

2 (3)

Pathological response to the neoadjuvant chemotherapy

Complete response (pT0)

28 (41)

Partial response (pT1/pTa/pTis)

14 (21)

No response

9 (13)

Progression (pT3 and/or N+)

17 (25)

  1. ’According to the TUR-BT pathology, imaging studies and clinical status.
  2. ”According to the pathological data from RC.
  3. 1Concomitant carcinoma in situ.
  4. 2Lymphovascular invasion.
  5. 39 patients (13%) received 2 cycles of NAC, 23 patients (34%) 3 cycles, 34 patients (50%) 4 cycles, and 1 patient 6 cycles.