Table 3 Associations between markers and chemotherapy response.

Variable		Complete vs. other			Complete/Partial vs. other			Other vs. progression
Variable		HR	95% CI	p-value	HR	95% CI	p-value	HR	95% CI	p-value
CD68	Low vs. high	0.72	0.27–1.91	0.50	1.13	0.42–3.023	0.81	1.63	0.52–5.078	0.40
CD68	Continuous	0.72	0.27–1.91	0.33	1.13	0.42–3.023	0.58	1.63	0.52–5.078	0.97
MAC387	Low vs. high	0.94	0.36–2.49	0.91	1.038	0.39–2.77	0.94	1.48	0.49–4.46	0.48
MAC387	Continuous	0.94	0.36–2.49	0.42	1.038	0.39–2.77	0.40	1.48	0.49–4.46	0.53
MAC387tumor¹	Low vs. high	3.57	0.90–14.13	0.070*	3.18	0.97–10.37	0.056*	3.76	1.10–12.82	0.034*
MAC387tumor¹	All groups 0–3	3.57	0.90–14.13	0.41	3.18	0.97–10.37	0.36	3.76	1.10–12.82	0.40
CLEVER-1m²	Low vs. high	1.63	0.62–4.32	0.33	2.78	1.006–7.67	0.049*	1.61	0.53–4.88	0.40
CLEVER-1m²	Continuous	1.63	0.62–4.32	0.49	2.78	1.006–7.67	0.21	1.61	0.53–4.88	0.88
CLEVER-1v³	Low vs. high	0.99	0.37–2.62	0.98	0.76	0.28–2.050	0.58	0.47	0.14–1.52	0.21
CLEVER-1v³	Continuous	0.99	0.37–2.62	0.26	0.76	0.28–2.050	0.10	0.47	0.14–1.52	0.012*

Regression analyses were used to evaluate the association between the chemotherapy response and marker groups dichotomized according to the mean value. Mann-Whitney U test was used to evaluate the association between the continuous variables and chemotherapy response. Pearson Chi-square/Fisher’s exact test was used to evaluate the association between MAC387⁺ tumor cells and chemotherapy response.
¹MAC387 positive tumor cells; low (score 0–2), high (score 3).
²CLEVER-1 positive macrophages.
³CLEVER-1 positive vessels.
^*Significant p-value.

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