Figure 2 | Scientific Reports

Figure 2

From: Low-dose YC-1 combined with glucose and insulin selectively induces apoptosis in hypoxic gastric carcinoma cells by inhibiting anaerobic glycolysis

Figure 2

Hypoxia-dependent apoptosis in 58As9 cells with YC-1 or YC-1 + GI treatment. (a) Cell viability in control and 10 μM YC-1-treated cells under normoxia or hypoxia was analyzed in the presence of G and/or I for 72 h. Fold change (FC) of hypoxia/normoxia is presented at the bottom. (b) Cell death rate in YC-1-, GI- and YC-1 + GI-treated cells under normoxia or hypoxia for 3 d. (c) Western blot analysis of cleaved-caspase3 and cleaved-PARP in YC-1-, YC-1 + G-, YC-1 + I- and YC-1 + GI-treated cells under hypoxia for 24 h. β-actin was equally expressed in all cells. ns: not significant, *p < 0.05, **p < 0.01.

Back to article page