Table 1 Distribution of clinical characteristics of METABRIC and TCGA breast cancer cohorts.
METABRIC | TCGA | |||||
|---|---|---|---|---|---|---|
Radiotherapy | p-value | Radiotherapy | p-value | |||
No | yes | No | yes | |||
Age (mean + /− st.dev) | 63.1 (12.8) | 59.7 (12.9) | 1.05E-08 | 59.8 (14.1) | 56.6 (12.0) | 1.69E-04 |
Age ≤ 60 years* | 303 | 572 | 223 | 322 | ||
Age > 60 years* | 500 | 599 | 206 | 220 | ||
Tumor size (mm; mean + /− st.dev) | 25.8 (13.3) | 26.5 (16.7) | 0.098 | Na | Na | Na |
Surgery* | 4.31E-14 | 2.27E-14 | ||||
Breast conserving | 80 | 705 | 48 | 231 | ||
Mastectomy | 712 | 458 | 269 | 200 | ||
ER status* | 0.29 | 0.81 | ||||
neg | 158 | 316 | 91 | 112 | ||
pos | 649 | 857 | 315 | 405 | ||
PR status* | 0.015 | 0.89 | ||||
neg | 359 | 581 | 130 | 164 | ||
pos | 448 | 592 | 273 | 353 | ||
Histological Grade* | 1.42E-09 | Na | Na | Na | ||
I | 85 | 84 | ||||
II | 353 | 418 | ||||
III | 309 | 643 | ||||
Stage* | 4.91E-09 | 7.15E-07 | ||||
0 | 9 | 3 | ||||
1 | 212 | 289 | 69 | 85 | ||
2 | 265 | 560 | 279 | 282 | ||
3 | 18 | 100 | 62 | 158 | ||
4 | 5 | 5 | 10 | 7 | ||
PAM50 subtype* | 6.91E-05 | 5.97E-01 | ||||
Luminal A | 322 | 378 | 159 | 188 | ||
Luminal B | 176 | 299 | 66 | 96 | ||
Her2 | 90 | 134 | 24 | 25 | ||
Basal | 68 | 141 | 46 | 69 | ||
