Figure 2
Mean (±SEM) amplitude of NMDA receptor-mediated currents recorded before and after bath application of 1 μM RO25–6981 in slices pre-incubated in aCSF (left panel) or aCSF+ 30 μM gabapentin (right panel) in CA1 pyramidal cells in slices from AIW animals (open circles) and AIE animals (closed circles). aIn the absence of gabapentin pre-incubation, current amplitudes in cells from AIE animals were higher than those in cells from AIW animals (p < 0.05) prior to application of RO25–6981. Following application of RO25–6981, current amplitudes were significantly reduced in cells from both AIWb and AIEc animals (p < 0.05). dThere was a similar main effect of RO25–6981 in slices that were pre-incubated in gabapentin (p < 0.05).
