Figure 2

Screening of the appropriate PCSK9 peptides vaccine. Compared to the control group, significant reduction in TC and LDL-C following PCSK9Qβ-003 vaccination was observed in Balb/c mice, while there was no significant difference in other vaccine groups. (a) TC was decreased in the PCSK9Qβ-003 vaccine group compared with the control group. (b) LDL-C level in the PCSK9Qβ-003 vaccine group was significantly decreased. (c,d) No significant difference of TG and HDL-C level was observed among all groups. (e) PCSK9Qβ-003 vaccine reduced TC in Balb/c mice since day 42 to the end of the study. n = 8 per group. Data are expressed as means ± SEM. *P < 0.05, **P < 0.01,***P<0.001 vs. the control group. ns: no significant difference.