Figure 3
PCSK9Qβ-003 vaccine decreased TC and LDL-C in LDLR+/− mice. (a) PCSK9Qβ-003 vaccine elicited strong antibody production against PCSK9-003 peptide after the second immunization in LDLR+/− mice. (b,c) Compared with the control group, TC and LDL-C level was decreased in the PCSK9Qβ-003 vaccine group. (d) PCSK9Qβ-003 vaccine lowered TC level from day 42 to the end of the study. (e,f) There was no significant difference of HDL-C and TG between the two groups. n = 8 per group. Data are expressed as means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 vs. the control group. ns: no significant difference.
