Figure 6
PCSK9Qβ-003 vaccine up-regulated LDLR expression and regulated lipid homeostasis. (a,b) Compared to the control group, the level of LDLR mRNA and protein expression in liver was increased obviously in the PCSK9Qβ-003 vaccine group, the samples derive from the same experiment and that blots were processed in parallel (the primary blots are presented in Supplementary Figure 2, 3). (c,d,e) PCSK9Qβ-003 vaccine up-regulated the mRNA level of SREBP-2, HNF-1α and HMG-CoA reductase. n = 8 per group. Data are expressed as means ± SEM. *P < 0.05, **P<0.01, ***P < 0.001 vs. the control group.
