Figure 1 | Scientific Reports

Figure 1

From: IRE1α/XBP1s branch of UPR links HIF1α activation to mediate ANGII-dependent endothelial dysfunction under particulate matter (PM) 2.5 exposure

Figure 1

PM2.5 exposure induced augmented serum ANGII and ACE/ANGII/AT1R axis components in rat vascular endothelial cells. (A) The serum level of ANGII was detected in SD rats IT instilled with PM2.5 or identical volume of sterile saline by ELISA (**P < 0.01). (B) Both AGT and ACE levels were detected in liver, kindey and heart of control and PM2.5-treated rats. The experimental results of 3 representative rats in each group were presented (C,D) The aortic endothelial cells were isolated from the above PM2.5-treated and control rats and then the transcription and protein synthesis of ACE/ANGII/AT1R axis components were determined, respectively.

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