Table 1 Enrichment of differentially expressed phosphorylated proteins and signaling pathways associated with aggressive biological behaviors after gemcitabine treatment.
Pathway Name | Pathway ID | Genes |
|---|---|---|
mTOR signaling pathway | hsa04150 | EIF4B, RPS6, MAPK1 |
HIF-1 signaling pathway | hsa04066 | EGFR, RPS6, MAPK1, LDHA |
MAPK signaling pathway | hsa04010 | STMN1, EGFR, MAPK14, MAPK1, NF1, FLNB |
VEGF signaling pathway | hsa04370 | MAPK14, MAPK1 |
PI3K-Akt signaling pathway | hsa04151 | HSP90AA1, EGFR, EIF4B, PKN2, RPS6, MAPK1 |
AMPK signaling pathway | hsa04152 | PRKAB1 |
Ras signaling pathway | hsa04014 | EGFR, RIN1, MAPK1, NF1 |
FoxO signaling pathway | hsa04068 | EGFR, SKP2, PRKAB1, USP7, MAPK14, MAPK1 |
NOD-like receptor signaling pathway | hsa04621 | HSP90AA1, ERBB2IP, MAPK14, MAPK1 |
Central carbon metabolism in cancer | hsa05230 | EGFR, MAPK1, LDHA |
Signaling pathways regulating pluripotency of stem cells | hsa04550 | MAPK14, MAPK1 |
