Table 2 Associations between CKD etiology associated SNPs and other CKD etiologies.

From: Associations between genetic risk variants for kidney diseases and kidney disease etiology

SNP Characteristics

IgA

MN

SLE

T1DM

GPA

SNP (Gene)

Effect allele

Chr. (Position)

Known locus

OR [95% CI]

P-value

OR [95% CI]

P-value

OR [95% CI]

P-value

OR [95% CI]

P-value

OR [95% CI]

P-value

rs4664308 (PLA2R1)

G

2 (160917497)

MN

(1.04 [0.87–1.25])

(6.5 ·10−1)

0.45 [0.34–0.60]

6.7 ·10 −8

(0.83 [0.61–1.13])

(2.5 ·10−1)

(1.36 [1.01–1.84])

(4.4 ·10−2)

(1.03 [0.79–1.36])

(8.1 ·10−1)

rs7574865 (STAT4)

G

2 (191964633)

SLE

(0.90 [0.74–1.11])

(3.4·10−1)

(0.96 [0.71–1.28])

(7.6 ·10−1)

0.53 [0.39–0.73]

9.7 ·10 −5

(0.85 [0.60–1.19])

(3.4 ·10−1)

(1.02 [0.74–1.40])

(9.2 ·10−1)

rs1150754 (TNXB)

T

6 (32050758)

SLE

(1.07 [0.83–1.40])

(5.9 ·10−1)

2.77 [2.06–3.71]

1.9 ·10−11

(1.97 [1.37–2.83])

(2.8 ·10 −4 )

2.53 [1.78–3.60]

2.5 ·10 −7

(0.94 [0.63–1.42])

(7.7 ·10−1)

rs660895 (HLA-DRB1)

G

6 (32577380)

IgA

(1.09 [0.86–1.37])

(4.7 ·10 −1 )

(0.60 [0.40–0.89])

(1.2 ·10−2)

(1.15 [0.77–1.71])

(5.1 ·10−1)

3.00 [2.17–4.18]

4.6 ·10 −11

1.81 [1.32–2.47]

2.0 ·10 −4

rs2187668 (HLA-DQA1)

T

6 (32605884)

MN

(0.93 [0.70–1.24])

(6.3 ·10−1)

4.48 [3.32–6.11]

2.4 ·10 −22

2.36 [1.63–3.42]

5.9 ·10 −6

(1.89 [1.27–2.80])

(1.6 ·10−3)

(0.75 [0.47–1.20])

(2.2 ·10−1)

rs1129740 (HLA-DQA1)

A

6 (32609105)

SSNS

(1.04 [0.88–1.24])

(6.4 ·10−1)

(1.69 [1.30–2.19])

8.4 ·10−5

(1.21 [0.89–1.62])

(2.2 ·10−1)

2.13 [1.52–2.97]

1.1 ·10−5

(1.18 [0.91–1.54])

(2.2 ·10−1)

rs9275596 (HLA-DQB1)

T

6 (32681631)

IgA

(1.20 [1.00–1.45])

(5.3 ·10 −2 )

0.52 [0.41–0.67]

3.3 ·10−7

(0.57 [0.41–0.77])

(3.4 ·10−4)

(1.20 [0.87–1.66])

(2.6 ·10−1)

(1.25 [0.94–1.67])

(1.2 ·10−1)

rs9277554 (HLA-DPB1)

T

6 (33055538)

GPA

(0.75 [0.61–0.92])

(6.5 ·10−3)

(1.04 [0.79–1.37])

(7.8 ·10−1)

(1.24 [0.91–1.69])

(1.7 ·10−1)

(1.05 [0.75–1.46])

(7.9 ·10−1)

0.14 [0.08–0.25]

1.7 ·10 −11

  1. MN: Membranous nephropathy, IgA: IgA nephropathy, SLE: Systemic lupus erythematosus, GPA: Granulomatosis with polyangiitis, T1DM: Type 1 diabetes mellitus, OR: Odds ratio, CI: Confidence interval. Bold: significant and independent association, italic: previously known association, simple style: significant, but dependent association. Numbers in brackets (): non-significant. For independence tests see Table 3. Significance threshold was set at 2.6 × 10−4 (Bonferroni correction: α = 0.05/(38*5)).
Back to article page