Table 2 Effects of ghrelin on body composition, and levels of glucose and insulin.

From: Ghrelin rescues skeletal muscle catabolic profile in the R6/2 mouse model of Huntington’s disease

 

WT vh

R6/2 vh

R6/2 ghrelin

p-value#

p-value§

Body composition

Fat mass (g)

7.5 ± 0.55

4.79 ± 0.64

6.36 ± 0.54

0.01

0.26

Lean mass (g)

24.77 ± 0.31

20.80 ± 0.49

21.63 ± 0.36

<0.0001

0.97

Fat mass (%)

21.87 ± 1.63

18.38 ± 2.22

22.45 ± 1.29

0.76

0.42

Lean mass (%)

78.12 ± 1.63

81.60 ± 2.21

77.57 ± 1.29

0.76

0.43

Glucose metabolism

Basal glucose (mmol/L)

9.70 ± 0.19

23.69 ± 2.98

19.81 ± 2.60

0.0002

>0.9999

Basal Insulin (μg/L)

2.31 ± 0.44

0.59 ± 0.15

1.16 ± 0.22

0.0007

0.28

AUC Insulin, 0–75 min

168 ± 29.57

18.85 ± 3.84

42.21 ± 7.79

0.0009

> 0.9999

HOMA-IR

24.57 ± 4.70

14.19 ± 2.85

27.86 ± 8.35

>0,9999

0,5157

HOMA-β

187.8 ± 36.79

21.61 ± 9.54

43.3 ± 9.35

0,0002

>0,9999

  1. The table shows the effects of ghrelin after 4 weeks of treatment. Data are expressed as mean ± SEM. Two-way ANOVA with Bonferroni post hoc test for multiple comparisons was used to analyse data. #Represents the p-value between WT and R6/2 treated with vehicle, and §represents the p-value between vehicle and ghrelin treatment in R6/2 mice. A p-value below 0.05 was considered significant.
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