Table 2 Predictive values (with 95% confidence intervals) of punctate lesions to estimate motor outcome with presence of any punctate lesions, punctate lesions in the corticospinal tracts, and more than 20 punctate lesions on conventional MR images.
Outcome measure | Presence of any PWML | Any PWML in corticospinal tracts | >20 PWML on MRI | |||
|---|---|---|---|---|---|---|
GMFCS 2–5 | Motor score <85 | GMFCS 2–5 | Motor score <85 | GMFCS 2–5 | Motor score <85 | |
Sensitivity | 0.71 (0.42–0.92) | 0.33 (0.2–0.49) | 0.64 (0.35–0.87) | 0.31 (0.18–0.47) | 0.5 (0.23–0.77) | 0.18 (0.08–0.32) |
Specificity | 0.73 (0.68–0.77) | 0.72 (0.67–0.76) | 0.82 (0.77–0.85) | 0.81 (0.77–0.85) | 0.98 (0.96–0.99) | 0.98 (0.96–0.99) |
Positive predictive value | 0.09 (0.04–0.15) | 0.13 (0.08–0.2) | 0.11 (0.05–0.2) | 0.18 (0.1–0.28) | 0.44 (0.2–0.7) | 0.5 (0.25–0.75) |
Negative predictive value | 0.98 (0.96–0.99) | 0.89 (0.85–0.93) | 0.96 (0.96–0.99) | 0.9 (0.8–0.93) | 0.98 (0.96–0.99) | 0.9 (0.87–0.93) |
Positive likelihood ratio | 2.62 (1.81–3.79) | 1.18 (0.75–1.15) | 3. 5 (2.24–5.46) | 1.68 (1–2.7) | 21.17 (9.22–48.6) | 7.78 (3.97–19.7) |
Negative likelihood ratio | 0.39 (0.17–0.90) | 0.93 (0.75–1.15) | 0.44 (0.22–0.88) | 0.85 (0.69–1.04) | 0.51 (0.3–0.86) | 0.84 (0.73–0.96) |
Diagnostic odds ratio | 6.65 (2.04–21.7) | 1.26 (0.65–2.46) | 7.99 (2.6–24.6) | 1.98 (0.99–3.93) | 41.3 (11.9–142.7) | 9.24 (3.28–26.07) |
