Figure 2 | Scientific Reports

Figure 2

From: Alleviative effects of fluoxetine on depressive-like behaviors by epigenetic regulation of BDNF gene transcription in mouse model of post-stroke depression

Figure 2

Fluoxetine was found to retrieve BDNF levels in the hippocampus of the PSD mice. (a,b) Total BDNF mRNA and protein levels in the hippocampus of the PSD mice were decreased significantly by RT-PCR (a) and Western blot (b) analysis (n = 6 per group, one-way ANOVA followed by Newman-Keuls multiple comparisons). (c,d) Fluoxetine treatment was found to increase the BDNF mRNA (c) and protein (d) expression of the PSD mice (n = 6 per group, one-way ANOVA followed by Newman-Keuls multiple comparisons). Full-length blots/gels are presented in Supplementary Figure 5. *P < 0.05, **P < 0.01 vs. sham group; #P < 0.05, ##P < 0.01 vs. PSDV group. Data are presented as the mean ± SEM. PSD: post stroke depression group; PSND: post stroke with non-depression group; PSDV: PSD with vehicle injection group; PSDF: PSD with fluoxetine injection group.

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