Figure 5 | Scientific Reports

Figure 5

From: Alleviative effects of fluoxetine on depressive-like behaviors by epigenetic regulation of BDNF gene transcription in mouse model of post-stroke depression

Figure 5

The treatment of fluoxetine cannot reverse the DNA methylation changes at the Bdnf promoter IV after PSD. (a) Quantification of the BDNF transcripts in the hippocampus among different groups by RT-PCR (n = 6 per group, one-way ANOVA followed by Newman-Keuls multiple comparisons). Illustration in the upper panel shows mice Bdnf exon gene structure (shown as boxes). (b) Quantification of the DNA methylation levels of Bdnf promoter IV in the hippocampus among different groups (n = 3 per group, one-way ANOVA followed by Newman-Keuls multiple comparisons). Illustration in the upper panel shows the mice Bdnf promoter IV gene structure.*P < 0.05, **P < 0.01 vs. sham group; ##P < 0.01 vs. PSD group. Data are presented as mean ± SEM. PSD: post stroke depression group; PSND: post stroke with non-depression group; PSDF: PSD with fluoxetine injection group.

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