Figure 4
From: Recombinant Incretin-Secreting Microbe Improves Metabolic Dysfunction in High-Fat Diet Fed Rodents
GLP-1-Expressing Lactobacillus paracasei Improves Glucose & Cholesterol Metabolism While Promoting Glucose-Dependant Insulin Secretion. Experiment II: HFC (n = 7) and LFC (n = 7) animals were assessed for 1 g/kg glucose (IPGTT) and 0.75 IU/kg insulin (ITT) tolerance at week 12 of feeding, prior to commencement of interventions. (A) IPGTT; (B) IPGTT area under the curve (AUC); (C) ITT; (D) ITT AUC. At week 22 of feeding/week 10 of intervention HFC (n = 7), PNZ (n = 14), GLP1 (n = 13) and LFC (n = 7) animals were again assessed for glucose and insulin tolerance. (E) IPGTT glucose levels; (F) IPGTT glucose AUC; (G) IPGTT insulin levels (T0 and T15); (H) IPGTT insulin AUC; (I) ITT glucose levels; (J) ITT glucose AUC. Animals were assessed for lipid and cholesterol metabolism by oral gavage with a complete meal (K,L) Ensure Plus, Abbott Nutrition). Data was analysed by one-way ANOVA with Bonferroni correction. Significant differences are represented by *(p < 0.05), **(p < 0.01), ***(p < 0.001), ****(p < 0.0001), where the asterisks are coloured according to the group which they represent. Plots depict replicates with mean and SEM.
