Table 4 Two-way gene–gene interaction models by using the GMDR method with adjustment for age and sex.

From: Transforming growth factor-β signaling pathway-associated genes SMAD2 and TGFBR2 are implicated in metabolic syndrome in a Taiwanese population

Phenotype

Two-way interaction model

Testing accuracy (%)

P value

MetS

SMAD2 rs11082639, TGFBR2 rs3773651

54.55

<0.001

High waist circumferencea

SMAD2 rs11082639, TGFBR2 rs3773651

50.68

0.278

High triglycerideb

SMAD2 rs11082639, TGFBR2 rs3773651

51.65

0.132

Low HDLc

SMAD2 rs11082639, TGFBR2 rs3773651

51.82

0.092

High blood pressured

SMAD2 rs11082639, TGFBR2 rs3773651

49.77

0.606

High fasting glucosee

SMAD2 rs11082639, TGFBR2 rs3773651

49.46

0.664

  1. GMDR = generalized multifactor dimensionality reduction, HDL cholesterol = high-density lipoprotein cholesterol, MetS = metabolic syndrome. P value was based on 1,000 permutations. Analysis was performed with adjustment for covariates including age and sex. P values of < 0.008 (Bonferroni correction: 0.05/6) are shown in bold. aWaist circumference ≥90 cm in male subjects, or waist circumference ≥80 cm in female subjects. bTriglyceride ≥1.7 mmol/L. cHDL <1.03 mmol/L in male subjects, or HDL < 1.29 mmol/L in female subjects. dSystolic blood pressure ≥130 mmHg or diastolic blood pressure ≥85 mmHg. eFasting glucose ≥5.6 mmol/L.
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