Figure 5 | Scientific Reports

Figure 5

From: Engraftment and morphological development of vascularized human iPS cell-derived 3D-cardiomyocyte tissue after xenotransplantation

Figure 5

TEM images of vascularized iPSC-CM 3D-tissues 28 days after implantation to rat infarcted heart. (a) The iPSC-CM forms numerous myofilaments into substantial myofibrils (mf), which distribute densely within the sarcoplasm. Many oval mitochondria (m) are seen ranging along the myofibrils. The arrow and arrowheads indicate adherens junction and desmosomes between adjacent iPSC-CMs, respectively. (b) The contact area between the adjacent iPSC-CMs shows substantial intercalated disk equipping gap junction (white arrowhead), adherens junction (white arrow) and desmosome (black arrowhead). The mitochondria (m) show many lamellar cristae. mf, myofibril; z, Z-band. (c) The iPSC-CMs in the deep region shows intracellular edema. (d) The endothelial cells (EC) form continuous capillary equipping substantial continuous basal lamina (white arrowheads) and pericyte (P). An erythrocyte are also seen in the vascular lumen.

Back to article page