Figure 5 | Scientific Reports

Figure 5

From: Transgenic mice lacking CREB and CREM in noradrenergic and serotonergic neurons respond differently to common antidepressants on tail suspension test

Figure 5

The effect of Creb1 deletion on mouse responsiveness on the TST after desipramine. (a) Immobility of control, Creb1DBHCre, and Creb1DBHCre/Crem−/− male mice on the TST after desipramine treatment (single dose, 20 mg/kg, i.p., 30 min. prior to the test) (ANOVA: F(3,25) = 9.25, p < 0.001; LSD post-hoc: *p < 0.05, **p < 0.01 vs control; ###p < 0.001 vs Creb1DBHCre). (b) Immobility of control, Creb1DBHCre, and Creb1DBHCre/Crem−/− female mice on the TST after desipramine treatment (single dose, 20 mg/kg, i.p., 30 min prior to the test) (ANOVA: F(3,19) = 8.71 p < 0.001; LSD post-hoc: **p < 0.01 vs control; ##p < 0.01 vs Creb1DBHCre). Data are the mean ± SEM, n = 4–9.

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