Figure 6 | Scientific Reports

Figure 6

From: Transgenic mice lacking CREB and CREM in noradrenergic and serotonergic neurons respond differently to common antidepressants on tail suspension test

Figure 6

The effect of Creb1 deletion on mouse responsiveness on the TST after fluoxetine. (a) Immobility of control, Creb1TPH2CreERT2, and Creb1TPH2CreERT2/Crem−/− male mice on the TST after fluoxetine treatment (single dose, 10 mg/kg, i.p., 30 min. prior to the test) (ANOVA: F(3,27) = 4.36 p < 0.05; LSD post-hoc test: *p < 0.05, **p < 0.01 vs control; #p < 0.05 vs Creb1TPH2CreERT2). (b) Immobility of control, Creb1TPH2CreERT2, and Creb1TPH2CreERT2/Crem−/− female mice on the TST after fluoxetine treatment (single dose, 10 mg/kg, i.p., 30 min prior to the test) (ANOVA: F(3,26) = 3.40 p < 0.05; LSD post-hoc test **p < 0.01 vs control). Data are the mean ± SEM, n = 5–10.

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