Figure 3
From: A chloroquine-induced macrophage-preconditioning strategy for improved nanodelivery
Effect of chloroquine on nanoparticle uptake in cancer cells. (a) Comparison of liposome (non-pegylated) uptake in macrophages (Raw 264.7, J774A.1, and Kupffer cells) and cancer cells (MDA-MB-231 breast cancer cells, MIA PaCa-2 pancreatic cancer cells, H358 lung cancer cells). (b) Viability of cancer cells in response to chloroquine and liposomes (6 h). (c) Effect of chloroquine on liposome uptake in MDA-MB-231 cells (6 h). Values are normalized to those of control cells. Data is presented as mean ± s.d. of triplicates. Statistics by Student’s t-test. **P < 0.01; ***P < 0.001, compared with cells exposed to liposomes.
