Figure 6
From: A chloroquine-induced macrophage-preconditioning strategy for improved nanodelivery
Effect of chloroquine on the biodistribution of silicon particles. (a) Stability of 89Zr-labeled silicon particles after 15 min in 50% mouse serum measured with a radio thin-layer chromatography (TLC) scanner. (b) Accumulation of intravenously injected 89Zr-labeled silicon particle in the blood, liver, spleen, and lungs. BALB/c mice were pretreated with chloroquine (60 mg/kg/day for 7 days). Organs were harvested 15 min after intravenous injection of silicon particles (8 × 107/mouse). (c) Blood/liver and blood/spleen accumulation ratio of 89Zr-labeled silicon particles (g tissue). Data is presented as mean ± s.d. (n = 5). Statistics by Student’s t-test. *P < 0.05; **P < 0.01; ***P < 0.001.
