Figure 7
TMRE uptake and 2-NBDG uptake are increased in 4T1 tumors relative to normal tissues. Normal and 4T1 dorsal window chambers were imaged with TMRE (first) and 2-NBDG (second) with a 10–15 min delay between injections. (a) Representative images for each test group. (b) Pixel distribution curves show the mean distribution of pixels from TMRE images taken at 45 minutes (TMRE45) for each group. (c) Pixel distribution curves show the mean distribution of pixels of delivery-corrected 2-NBDG images taken at 60 minutes (2-NBDG60/RD) for each group. NS = not significant. N = 3–5 mice/group. Comparison of mean pixel distribution curves across animal groups was performed with a Kolmogorov-Smirnov (KS) test using the MATLAB (Mathworks, USA).
