Table 2 Univariable and multivariable meta-regression for outcome IS/AAR.
Univariable Analysis | Multivariable analysis | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Variable | categories | n | mean (95%CI) | p-value | post-hoc p-value | Variable | p-value | beta | post-hoc p-value |
Species | Dog | 122 | 46.4 (43.1–49.7) | <0.001 | 0.001 (pig vs dog) | Species | <0.001 | +21.6 if pig (vs dog) | <0.001 |
Pig | 41 | 59.3 (53.6–65.0) | 0.552 (pig vs sheep) | +1.8 if pig (vs sheep) | 0.874 | ||||
Sheep | 2 | 67.5 (41.0–93.9) | 0.120 (dog vs sheep) | −19.8 if dog (vs sheep) | 0.071 | ||||
Sex | Male | 45 | 47.7 (41.9–53.4) | 0.80 | All comparisons NS | Sex | 0.07 | +10.5 if male (vs female) | 0.114 |
Female | 11 | 50.0 (38.4–61.6) | +10.4 if male (vs unknown) | 0.010 | |||||
Both | 78 | 51.3 (46.9–55.6) | −0.1 if female (vs unknown) | 0.990 | |||||
Unknown | 31 | 49.5 (42.6–56.4) | +6.3 if male (vs both) | 0.040 | |||||
−4.1 if female (vs both) | 0.491 | ||||||||
+4.0 if both (vs unknown) | 0.255 | ||||||||
Immunosupp | not applicable | Immunosupp | not applicable | ||||||
Comedication | yes | 7 | 43.6 (29.2–58.0) | 0.379 |  | Comedication | 0.01 | −18.2 if used |  |
no | 158 | 50.2 (47.1–53.2) | |||||||
Open vs closed model | Open | 129 | 50.3 (46.9–53.7) | 0.536 | 0.293 (open vs closed) | Open vs closed model | 0.22 | +4.9 if open (vs closed) | 0.130 |
Closed | 35 | 46.7 (40.2–53.3) | 0.745 (open vs unknown) | −13.1 if open (vs unknown) | 0.433 | ||||
Unknown | 1 | 57.0 (18.7–95.3) | 0.603 (closed vs unknown) | −17.9 if closed (vs unknown) | 0.287 | ||||
Occlusion | Permanent | 17 | 69.1 (60.5–77.7) | <0.001 | <0.001 (permanent vs temporary) | Occlusion | <0.001 | +36.3 if permanent (vs temporary) | <0.001 |
Temporary | 145 | 47.2 (44.2–50.2) | 0.072 (permanent vs unknown) | −9.2 if permament (vs unknown) | 0.343 | ||||
not known | 3 | 65.9 (45.8–86.0) | 0.774 (temporary vs unknown) | −45.7 if temporary (vs unknown) | <0.001 | ||||
Occluded vessel | LAD | 108 | 54.3 (50.8–57.7) | <0.001 | <0.001 (LAD vs LCX) | Occluded vessel | 0.03 | +7.6 if LAD (vs LCX) | 0.008 |
LCX | 53 | 40.6 (35.6–45.6) | 0.921 (LAD vs LAD/LCX) | +2.2 if LAD (vs LAD/LCX) | 0.788 | ||||
LAD/LCX | 4 | 55.2 (36.9–73.5) | 0.13 (LCX vs LAD/LCX) | −5.4 if LCX (vs LAD/LCX) | 0.523 | ||||
Quantification method | TTC | 140 | 49.1 (45.8–52.3) | 0.30 | All comparisons NS | Quantification method | 0.17 | All comparisons NS |  |
Nitro blue | 10 | 60.6 (48.7–72.5) |  |  |  |  |  |  | |
Planimetry | 11 | 48.6 (37.2–60.0) |  |  |  |  |  |  | |
|  | Other§ | 4 | 54.1 (35.2–72.9) |  |  |  |  |  |  |
Follow-up duration | 165 | −0.02/hour (−0.05–0.01) | 0.12 |  | Follow-up duration | 0.011 | −0.03/hour |  | |
Study Quality | 165 | +0.36/point (−1.7–2.4) | 0.734 |  | Study quality | 0.945 | +0.07/point |  | |
Ischemia time | 145 | −0.01/min (−0.07–0.05) | 0.723 |  | Ischemia time*(n = 56) | 0.001 | +0.09/min |  | |
Weight | 159 | +0.48/kg (0.219–0.743) | <0.001 |  | Weight*(n = 159) | 0.124 | +0.25/kg |  | |
Age | 5 | −0.25/wk (−3.24–2.74) | 0.806 |  | Age*(n = 5) | not applicable | |||
