Figure 6
From: Conformational stabilization as a strategy to prevent nucleophosmin mislocalization in leukemia
Subcellular localization of YFP-NPM (wild type, mutant E or mutant A) in examples of untreated HeLa cells or treated with compounds C1 and C3. Confocal microscopy images of HeLa cells in the absence or presence of 50 μM C1 or C3. YFP fluorescence is shown in green and DNA, stained with DAPI, in blue. Bright green fluorescence dots in the cytoplasm of cells transfected with the mutants are assigned to protein aggregates (arrows, see text).
