Table 4 Comparison of target and OARs’ dose-volume parameters in the subgroup of larger tumor volume (PTV ≥ 312 mm3) and smaller tumor volume (PTV < 312 mm3).

From: Dosimetric comparison of the helical tomotherapy, volumetric-modulated arc therapy and fixed-field intensity-modulated radiotherapy for stage IIB-IIIB non-small cell lung cancer

   

TOMO

VMAT

IMRT

P value

T vs. V

T vs. I

V vs. I

PTV ≥ 312mm3

PTV

CI

0.77 ± 0.06

0.81 ± 0.05

0.73 ± 0.07

0.057

0.155

0.002

HI

0.15 ± 0.05

0.10 ± 0.03

0.12 ± 0.02

0.034

0.083

0.051

Heart

MHD (Gy)

18.21 ± 9.50

12.76 ± 8.15

12.56 ± 7.24

0.118

0.040

0.527

V5 (%)

63.63 ± 27.74

47.16 ± 27.96

46.99 ± 22.79

0.155

0.032

0.714

V10 (%)

50.96 ± 28.13

35.49 ± 25.31

34.82 ± 20.53

0.146

0.035

0.719

V20 (%)

37.90 ± 24.22

24.82 ± 19.85

24.22 ± 17.83

0.134

0.034

0.631

PTV < 312 mm3

PTV

CI

0.76 ± 0.07

0.80 ± 0.08

0.76 ± 0.05

0.122

0.836

0.101

HI

0.13 ± 0.04

0.10 ± 0.03

0.10 ± 0.01

0.015

0.014

0.877

Heart

V5 (%)

39.46 ± 23.05

38.37 ± 24.90

30.51 ± 22.67

0.900

0.000

0.350

  1. Abbreviation: OAR = organs at risk; PTV = planning target volume; CI = conformity index; HI = heterogeneity index; T = helical tomotherapy; V = volumetric-modulated arc therapy; I = intensity-modulated radiotherapy; MHD = mean heart dose.
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