Table 1 Characteristics of included studies. NA = not available, DM = diabetes mellitus, NOS = The Newcastle–Ottawa scale.
Study ID | Country/province | Study design | Follow up duration | No. of eyes Gender (M/F) | Age (year/SD, range) | Diabetes condition | Quality control (NOS) | ||
---|---|---|---|---|---|---|---|---|---|
Normal | DM | Normal | DM | ||||||
Li19 | China Hainan | Prospective controlled study | 3 months | 106/84 | 101/85 | 65.1 (12.3) | 64.6 (12.5) | NA | 7 |
Misra27 | New Zealand | Prospective cohort study | 6 months | 23 | 28 | 74.4 (7.4) | 71.2 (7.6) | Duration (11.54 years) HbA1c% (DM:nDM 7.5:5.7, P < 0.001) | 8 |
Zhu28 | China Beijing | Prospective controlled study | 1 month | 16/17 | 15/20 | 60–80 | 60–80 | Blood glucose < 8.3 mmol/L, diabetic course > 5a | 8 |
Yan29 | China Guizhou | Prospective controlled study | 3 months | 30/32 | 51/46 | 69.6 (55–85) | 65.6 (52–82) | Diabetic course > 10a, Diabetic course < 10a | 8 |
Su30 | China Liaoning | Prospective controlled study | 1 month | 31 | 39 | 50–80 | 50–80 | Blood glucose < 8.3 mmol/L, diabetic course < 15a | 8 |
Liu31 | China Hebei | Prospective controlled study | 1 week | 16/14 | 17/13 | 64.7 (3.6) | 69.6 (5.4) | NA | 8 |
Zhao32 | China Shandong | Prospective controlled study | 3 months | 24/26 | 26/24 | 64.8 (55–83) | 63.2 (52–80) | NA | 8 |
Wang33 | China inner Mongolia | Prospective controlled study | 6 months | 36/24 | 24/16 | 69.2 (8.2) | 65.3 (11) | NA | 7 |
Yang34 | China Guangzhou | Prospective controlled study | 3 months | 33/32 | 34/41 | 68.1 (50–84) | 67.8 (51–83) | Blood glucose < 6. 6–10 mmol/L Duration (1–17 years) | 8 |
Hugod35 | Denmark | Prospective controlled study | 3 months | 30 | 30 | 75.4 (9.3) | 75.6 (8.6) | HbA1c%(7.08 (1.43)) | 8 |
Wu36 | China Shaanxi | Prospective controlled study | 3 months | 31 | 28 | 50–80 | 50–80 | Diabetic course < 12a | 7 |
Wu37 | China Hainan | Prospective controlled study | 3 months | 33/31 | 26/24 | 65.6 (52–82) | 66.8 (50–84) | NA | 8 |
Morikubo17 | Japan | Prospective controlled study | 1 month | 93 | 93 | 68.8 (8.9) | 68.6 (8.8) | NA | 8 |