Figure 7 | Scientific Reports

Figure 7

From: Network pharmacology exploration reveals endothelial inflammation as a common mechanism for stroke and coronary artery disease treatment of Danhong injection

Figure 7

The effects of DHI on expression of IL-1β, IL-10 and TNF-α induced by different stimulants. EA.hy926 cells were pre-treated with different concentrations of DHI (1/800, 1/1600 and 1/3200 dilutions) for 1 h, and then stimulated with LPS, ox-LDL or CHC for 18 h respectively. Cell supernatants were collected to detect cytokines IL-1β, IL-10 and TNF-α levels. (A–I) IL-1β, IL-10 and TNF-α levels were promoted by 10 μg/mL LPS, 100 μg/mL ox-LDL and 100 μg/mL CHC. (A–C) DHI effects on LPS, ox-LDL or CHC-stimulated IL-1β level. (D–F) DHI effects on LPS, ox-LDL or CHC- stimulated IL-10 level. (G–I) DHI effect on LPS, ox-LDL or CHC-stimulated TNF-α level. Data are presented as mean ± SD (n = 3). *P < 0.05 versus control; **P < 0.01 versus control; #P < 0.05 versus LPS, ox-LDL or CHC group; ##P < 0.01 versus LPS, ox-LDL or CHC group.

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