Figure 6
Antagonists of TSPO and GABAA receptor inhibited koumine’s analgesic effects on POP in rats. Effect of koumine (200 μg), PK11195 (0.7, 7 μg), bicuculline (0.8, 8 μg) and their co-administration on peak %MPE for MWL (A) and TWL (B) 60 min after treatment on the first day post-incision, respectively. Koumine was injected intrathecally preceded by vehicle or various antagonists including PK11195 and bicuculline. Abbreviations; KM: koumine, BIC: bicuculline. Data are presented as mean ± SEM. **P < 0.01, ***P < 0.001 versus vehicle group, ### P < 0.001 versus koumine alone group. One-way ANOVA followed by the LSD post hoc test. Each group consisted of 5–12 rats.
