Table 1 Characteristics and distribution of overall cohort (n[%]).

From: Serum Levels of M2BPGi as Short-Term Predictors of Hepatocellular Carcinoma in Untreated Chronic Hepatitis B Patients

 

Controls

HCC cases: stratified by collection time (years prior to HCC diagnosis)

 

Non-LC Controls (n = 546)

LC6 Controls (n = 167)

1–2 years (n = 58)

2–5 years (n = 103)

≥5 years (n = 196)

P-value (comparing time points of HCC)

P-value (all HCC cases vs. all controls)

Age (mean years [sd])

61.7 (8.4)

58.8 (8.5)

61.2 (8.8)

59.1 (9.7)

52.5 (9.3)

<0.001

<0.001

Gender

Female

162 (29.7)

39 (23.4)

11 (19.0)

18 (17.5)

46 (23.5)

  

Male

384 (70.3)

128 (76.7)

47 (81.0)

85 (82.5)

150 (76.5)

0.44

0.01

ALT (U/L)1

 < 45

477 (90.9)

144 (88.3)

39 (72.2)

58 (63.7)

154 (82.4)

  

≥45

48 (9.1)

19 (11.7)

15 (27.8)

33 (36.3)

33 (17.7)

0.003

 < 0.001

AST (U/L)2

 < 45

497 (94.7)

138 (84.7)

39 (72.2)

56 (61.5)

154 (83.2)

  

≥45

28 (5.3)

25 (15.3)

15 (27.8)

35 (38.5)

31 (16.8)

 < 0.001

 < 0.001

AFP (ng/mL)3

0–10

489 (97.0)

148 (90.8)

31 (54.4)

72 (71.3)

149 (79.3)

  

≥10

15 (3.0)

15 (9.2)

26 (45.6)

29 (28.7)

39 (20.7)

 < 0.001

 < 0.001

HBV DNA level (copies/mL)4

Mean log10 copies/mL [sd]

3.4 (3.2)

3.9 (3.1)

4.7 (3.4)

5.5 (2.4)

5.3 (1.9)

0.13

 < 0.001

<300

139 (29.1)

35 (21.7)

10 (18.5)

9 (9.6)

14 (7.7)

  

300–9999

103 (21.6)

31 (19.3)

5 (9.3)

11 (11.7)

32 (17.6)

  

10,000–99,999

75 (15.7)

28 (17.4)

6 (11.1)

11 (11.7)

33 (18.1)

  

100,000–999,999

54 (11.3)

19 (11.8)

5 (9.3)

16 (17.0)

27 (14.8)

  

≥1,000,000

107 (22.4)

48 (29.8)

28 (51.9)

47 (50.0)

76 (41.8)

0.11

 < 0.001

HBsAg (IU/mL)5

Mean log10 IU/mL [sd]

1.6 (1.9)

2.2 (1.7)

2.6 (1.6)

2.8 (1.3)

3.0 (1.4)

0.18

 < 0.001

<100

240 (45.5)

43 (26.7)

10 (18.9)

17 (17.4)

25 (13.4)

  

100–999

145 (27.5)

49 (30.4)

13 (24.5)

26 (26.5)

51 (27.4)

  

≥1,000

142 (26.9)

69 (42.9)

30 (56.6)

55 (56.1)

110 (59.1)

0.85

 < 0.001

M2BPGi level (index)

Mean [sd]

0.9 (0.6)

1.9 (3.3)

3.3 (3.9)

2.6 (2.8)

1.2 (0.9)

 < 0.001

 < 0.001

Negative (C.O.I < 1.00)7

339 (62.1)

95 (56.9)

15 (25.9)

34 (33.0)

107 (54.6)

  

1.00 < C.O.I < 2.00

181 (33.2)

40 (23.9)

17 (29.3)

30 (29.1)

62 (31.6)

  

C.O.I ≥2.00

26 (4.8)

32 (19.2)

26 (44.8)

39 (37.9)

27 (13.8)

 < 0.001

 < 0.001

  1. 1Data missing for 50 samples; 2Data missing for 52 samples; 3Data missing for 57 samples; 4Data missing for 95 samples; 5Data missing for 45 samples; 6LC = cirrhosis. 7C.O.I = Cut Off Index.
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