Table 2 Prediction of overall HCC at three separate time-points (546 controls vs. 357 cases).
Time between sample collection and HCC diagnosis | |||
|---|---|---|---|
1–2 years (58 cases) | 2–5 years (103 cases) | ≥5 years (196 cases) | |
Adjusted OR (95% CI) | Adjusted OR (95% CI) | Adjusted OR (95% CI) | |
M2BPGi level (index) | |||
Negative (C.O.I < 1.00) | 1.00 | 1.00 | 1.00 |
1.00 < C.O.I < 2.00 | 1.64 (0.69–3.91) | 1.31 (0.65–2.63) | 1.06 (0.64–1.74) |
C.O.I ≥ 2.00 | 7.40 (2.40–22.78)c | 6.46 (2.58–16.18)c | 2.24 (0.97–5.15) |
Age (in years) | |||
30–39 | 1.00 | 1.00 | 1.00 |
40–49 | 0.87 (0.25–3.05) | 0.50 (0.21–1.19) | 0.46 (0.27–0.78)b |
50–59 | 0.69 (0.20–2.39) | 0.43 (0.18–1.02) | 0.22 (0.13–0.39)c |
≥ 60 | 1.45 (0.37–5.65) | 0.69 (0.24–1.96) | 0.05 (0.01–0.20)c |
Sex | |||
Female | 1.00 | 1.00 | 1.00 |
Male | 1.35 (0.50–3.63) | 1.54 (0.66–3.58) | 1.09 (0.64–1.86) |
ALT (U/L) | |||
<45 | 1.00 | 1.00 | 1.00 |
≥ 45 | 1.19 (0.40–3.54) | 1.29 (0.58–2.88) | 0.92 (0.42–2.01) |
AST (U/L) | |||
< 45 | 1.00 | 1.00 | 1.00 |
≥ 45 | 0.77 (0.21–2.83) | 3.00 (1.26–7.15)a | 1.20 (0.50–2.90) |
AFP (ng/mL) | |||
< 10 | 1.00 | 1.00 | 1.00 |
≥ 10 | 12.99 (4.82–35.03)c | 5.40 (2.17–13.45)c | 5.34 (2.43–11.70)c |
HBV DNA level (copies/mL) | |||
< 300 | 1.00 | 1.00 | 1.00 |
300–9999 | 0.23 (0.05–1.06) | 1.12 (0.34–3.66) | 1.34 (0.59–3.06) |
10,000–99,999 | 0.27 (0.06–1.24) | 0.96 (0.27–3.49) | 1.05 (0.44–2.52) |
100,000–999,999 | 0.22 (0.04–1.27) | 2.32 (0.70–7.68) | 1.07 (0.42–2.70) |
≥ 1,000,000 | 0.41 (0.10–1.61) | 1.22 (0.37–4.06) | 1.03 (0.43–2.44) |
HBsAg (IU/mL) | |||
<100 | 1.00 | 1.00 | 1.00 |
100–999 | 2.85 (0.79–10.29) | 2.16 (0.83–5.64) | 3.19 (1.56–6.55)b |
≥1,000 | 4.51 (1.21–16.77)a | 2.77 (1.02–7.53)a | 5.28 (2.55–10.93)c |
