Figure 4
From: Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein
Ncd Y433 and nucleotide release. (A) Ncd α4/α6 binding cleft. Ncd-ADP H1 (PDB 5W3D; α4/α6, green) superposed with H2 (white). Ncd H1 β3, Y433 and P-loop, yellow green; H1 and H2 Mg+2, yellow green; ADP, red. (B) Fo–Fc difference maps of ADP bound to Ncd H1 and H2. Density for the ADP ribose moiety in H2 is less well defined than in H1 and the magnesium ion has moved further away from the beta phosphate in H2 than in H1.
