Table 4 In vitro Caco-2 permeability data of compounds.

From: Novel Benzylidene Thiazolidinedione Derivatives as Partial PPARγ Agonists and their Antidiabetic Effects on Type 2 Diabetes

Compound

Avg Papp × 10−6 cm/sec; n = 2

A to B

B to A

Efflux Ratio (B > A/A > B)

Permeability Rank1

1a

2.4

14.3

2.1

Low

1i

23.0

51.2

2.7

High

3a

1.6

19.3

3.2

Low

  1. All permeability values are represented as Avg Papp × 10−6 cm/sec. 1Permeability ranking is based on following criteria (in hours): Low, Papp,A-B < 5 × 10−6 cm/sec; High, Papp,A-B ≥ 5 × 10−6 cm/sec. Cell growth media, DMEM, 10% FBS, Gentamycin; test conc: 2 µM; incubation period, 150 min; apical/donor pH, 6.5/7.4.
Back to article page