Table 5 In vitro MDCK-II permeability data of compounds.

From: Novel Benzylidene Thiazolidinedione Derivatives as Partial PPARγ Agonists and their Antidiabetic Effects on Type 2 Diabetes

Compound

Avg Papp × 10−6 cm/sec; n = 2

A to B

B to A

Efflux Ratio (B > A/A > B)

Permeability Rank1

1a

1.8

2.5

1.4

Low

1i

16.3

11.9

0.7

High

3a

0.8

0.4

0.5

Low

  1. All permeability values are represented as Avg Papp × 10−6 cm/sec. 1Permeability ranking is based on following criteria (in hours): Low, Papp,A-B < 5 × 10−6 cm/sec; High, Papp,A-B ≥ 5 × 10−6 cm/sec. Cell growth media, MEM-alpha with MEM NEAA-glutamine-penicillin-streptomycin; test conc: 2 µM; incubation period, 150 min; apical/donor pH, 7.4/7.4; NA, not applicable.
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